Publications

  1. Cheng J, Chen C, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ. Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping. Toxicol Sci. 2013 Sep;135(1):37-47. doi: 10.1093/toxsci/kft143. Epub 2013 Jun 28. PubMed PMID: 23811823; PubMed Central PMCID: PMC3748767.
  2. Adler V, Bowne W, Kamran I, Michl J, Friedman FK, Chin E, Zenilman M, Pincus MR. Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells. Cancer Chemother Pharmacol. 2008 Aug;62(3):491-8. doi: 10.1007/s00280-007-0630-5. Epub 2007 Dec 8. PubMed PMID: 18066549.
  3. Adler V, Bowne W, Michl J, Sookraj KA, Ikram K, Pestka S, Izotova L, Zenilman M, Friedman FK, Qu Y, Pincus MR. Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase. Ann Clin Lab Sci. 2008 Winter;38(1):47-56. PubMed PMID: 18316782.
  4. Qu Y, Adler V, Izotova L, Pestka S, Bowne W, Michl J, Boutjdir M, Friedman FK, Pincus MR. The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type–but not by oncogenic–ras-p21 protein. Front Biosci. 2007 Sep 1;12:5089-97. PubMed PMID: 17569632.
  5. Smith SV, Robinson RC, Smith TG, Burks SM, Friedman FK. Rapid conformational dynamics of cytochrome P450 2E1 in a natural biological membrane environment. 2006 Dec 26;45(51):15617-23. doi: 10.1021/bi061873u. PubMed PMID: 17176083.
  6. Michl J, Scharf B, Schmidt A, Huynh C, Hannan R, von Gizycki H, Friedman FK, Brandt-Rauf P, Fine RL, Pincus MR. PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. Int J Cancer. 2006 Oct 1;119(7):1577-85. doi: 10.1002/ijc.22029. PubMed PMID: 16688716.
  7. Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway. 2005 Aug 16;44(32):10784-95. doi: 10.1021/bi050619j. PubMed PMID: 16086581.
  8. Friedman FK, Robinson RC, Dai R. Molecular modeling of mammalian cytochrome P450s. Front Biosci. 2004 Sep 1;9:2796-806. Review. PubMed PMID: 15353315.
  9. Chie L, Adler V, Friedman FK, Chung D, Pincus MR. An effector peptide from glutathione-S-transferase-pi strongly and selectively blocks mitotic signaling by oncogenic ras-p21. Protein J. 2004 Apr;23(3):235-8. PubMed PMID: 15200055.
  10. Chie L, Friedman FK, Duncan T, Chen JM, Chung D, Pincus M. Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling. Protein J.2004 Apr;23(3):229-34. PubMed PMID: 15200054.
  11. Duncan T, Chen JM, Friedman FK, Hyde M, Chie L, Pincus MR. Comparison of molecular dynamics averaged structures for complexes of normal and oncogenic ras-p21 with SOS nucleotide exchange protein, containing computed conformations for three crystallographically undefined domains, suggests a potential role of these domains in ras signaling. Protein J. 2004 Apr;23(3):217-28. PubMed PMID: 15200053.
  12. Bustin M, Robinson RC, Friedman FK. Immunochemical analysis of chromatin. Methods Enzymol. 2004;376:209-20. doi: 10.1016/S0076-6879(03)76014-5. Review. PubMed PMID: 14975308.
  13. Kanovsky M, Michl J, Botzolaki G, Morin J, Kovac C, Chung DL, Chie L, Friedman FK, Pincus MR. Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth. Cancer Chemother Pharmacol. 2003 Sep;52(3):202-8. doi: 10.1007/s00280-003-0639-3. Epub 2003 May 29. PubMed PMID: 12783204.
  14. Do TN, Rosal RV, Drew L, Raffo AJ, Michl J, Pincus MR, Friedman FK, Petrylak DP, Cassai N, Szmulewicz J, Sidhu G, Fine RL, Brandt-Rauf PW. Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site. 2003 Mar 13;22(10):1431-44. doi: 10.1038/sj.onc.1206258. PubMed PMID: 12629507.
  15. Chen JM, Friedman FK, Brandt-Rauf PW, Pincus MR, Chie L. Comparison of the average structures, from molecular dynamics, of complexes of GTPase activating protein (GAP) with oncogenic and wild-type ras-p21: identification of potential effector domains. J Protein Chem. 2002 Jul;21(5):349-59. PubMed PMID: 12206509.
  16. Friedman FK, Chie L, Chung D, Robinson R, Brandt-Rauf P, Yamaizumi Z, Pincus MR. Inhibition of ras-induced oocyte maturation by peptides from ras-p21 and GTPase activating protein (GAP) identified as being effector domains from molecular dynamics calculations. J Protein Chem. 2002 Jul;21(5):361-6. PubMed PMID: 12206510.
  17. Chie L, Friedman FK, Kung HF, Lin MC, Chung D, Pincus MR. Identification of the site of inhibition of mitogenic signaling by oncogenic ras-p21 by a ras effector peptide. J Protein Chem. 2002 Jul;21(5):367-70. PubMed PMID: 12206511.
  18. Hadjokas NE, Dai R, Friedman FK, Spence MJ, Cusack BJ, Vestal RE, Ma Y. Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells. Br J Pharmacol. 2002 Jun;136(3):347-52. doi: 10.1038/sj.bjp.0704711. PubMed PMID: 12023936; PubMed Central PMCID: PMC1573356.
  19. Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, Rubinstein P, Visser J, Robinson R, Brandt-Rauf PW, Michl J, Fine RL, Pincus MR. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438-43. doi: 10.1073/pnas.211280698. Epub 2001 Oct 16. PubMed PMID: 11606716; PubMed Central PMCID: PMC60072.
  20. Piro MC, Militello V, Leone M, Gryczynski Z, Smith SV, Brinigar WS, Cupane A, Friedman FK, Fronticelli C. Heme pocket disorder in myoglobin: reversal by acid-induced soft refolding. 2001 Oct 2;40(39):11841-50. doi: 10.1021/bi010652f. PubMed PMID: 11570884.
  21. Ranginwale M, Smith S, Flom J, Chie L, Kanovsky M, Chung D, Friedman FK, Robinson RC, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR. Differences in patterns of activation of MAP kinases induced by oncogenic ras-p21 and insulin in oocytes. Exp Cell Res. 2001 Sep 10;269(1):162-9. doi: 10.1006/excr.2001.5311. PubMed PMID: 11525649.
  22. Kovac C, Clie L, Morin J, Friedman FK, Robinson R, Chung DL, Kanovsky M, Flom J, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR. Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation.Cancer Chemother Pharmacol. 2001 Jul;48(1):9-14. PubMed PMID: 11488531.
  23. Chen JM, Rijhwani K, Friedman FK, Hyde MJ, Pincus MR. Identification, using molecular dynamics, of an effector domain of the ras-binding domain of the raf-p74 protein that is uniquely involved in oncogenic ras-p21 signaling. J Protein Chem. 2000 Oct;19(7):545-51. PubMed PMID: 11233167.
  24. Sapone A, Peters JM, Sakai S, Tomita S, Papiha SS, Dai R, Friedman FK, Gonzalez FJ. The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.2000 Jun;10(4):321-33. PubMed PMID: 10862523.
  25. Smith SV, Koley AP, Dai R, Robinson RC, Leong H, Markowitz A, Friedman FK. Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: a CO flash photolysis study. 2000 May 16;39(19):5731-7. doi: 10.1021/bi000129l. PubMed PMID: 10801323.
  26. Dai R, Pincus MR, Friedman FK. Molecular modeling of mammalian cytochrome P450s. Cell Mol Life Sci. 2000 Mar;57(3):487-99. doi: 10.1007/PL00000709. Review. PubMed PMID: 10823248.
  27. Omata Y, Dai R, Smith SV, Robinson RC, Friedman FK. Synthetic peptide mimics of a predicted topographical interaction surface: the cytochrome P450 2B1 recognition domain for NADPH-cytochrome P450 reductase. J Protein Chem. 2000 Jan;19(1):23-32. PubMed PMID: 10882169.
  28. Chie L, Amar S, Kung HF, Lin MC, Chen H, Chung DL, Adler V, Ronai Z, Friedman FK, Robinson RC, Kovac C, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR. Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway. Cancer Chemother Pharmacol.2000;45(6):441-9. PubMed PMID: 10854130.
  29. Pincus MR, Brandt-Rauf PW, Michl J, Carty RP, Friedman FK. ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents. Cancer Invest. 2000;18(1):39-50. Review. PubMed PMID: 10701366.
  30. Chen JM, Friedman FK, Hyde MJ, Monaco R, Pincus MR. Molecular dynamics analysis of the structures of ras-guanine nucleotide exchange protein (SOS) bound to wild-type and oncogenic ras-p21. Identification of effector domains of SOS.J Protein Chem. 1999 Nov;18(8):867-74. PubMed PMID: 10839623.
  31. Chie L, Chen JM, Friedman FK, Chung DL, Amar S, Michl J, Yamaizumi Z, Brandt-Rauf PW, Pincus MR. Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain. J Protein Chem. 1999 Nov;18(8):881-4. PubMed PMID: 10839625.
  32. Monaco R, Friedman FK, Hyde MJ, Chen JM, Manolatus S, Adler V, Ronai Z, Koslosky W, Pincus MR. Identification of a glutathione-S-transferase effector domain for inhibition of jun kinase, by molecular dynamics. J Protein Chem. 1999 Nov;18(8):859-66. PubMed PMID: 10839622.
  33. Chie L, Chen JM, Friedman FK, Chung DL, Amar S, Michl J, Yamaizumi Z, Brandt-Rauf PW, Pincus MR. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21. J Protein Chem. 1999 Nov;18(8):875-9. PubMed PMID: 10839624.
  34. Wei X, Dai R, Zhai S, Thummel KE, Friedman FK, Vestal RE. Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide. J Pharmacol Exp Ther. 1999 May;289(2):853-8. PubMed PMID: 10215663.
  35. Dai R, Zhai S, Wei X, Pincus MR, Vestal RE, Friedman FK. Inhibition of human cytochrome P450 1A2 by flavones: a molecular modeling study. J Protein Chem. 1998 Oct;17(7):643-50. PubMed PMID: 9853678.
  36. Zhai S, Dai R, Friedman FK, Vestal RE. Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids.Drug Metab Dispos. 1998 Oct;26(10):989-92. PubMed PMID: 9763404.
  37. Dai R, Pincus MR, Friedman FK. Molecular modeling of cytochrome P450 2B1: mode of membrane insertion and substrate specificity. J Protein Chem. 1998 Feb;17(2):121-9. PubMed PMID: 9535274.
  38. Zhai S, Dai R, Wei X, Friedman FK, Vestal RE. Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes. Life Sci. 1998;63(8):PL119-23. doi: 10.1016/s0024-3205(98)00323-3. PubMed PMID: 9718089.
  39. Cupane A, Leone M, Militello V, Friedman FK, Koley AP, Vasquez GB, Brinigar WS, Karavitis M, Fronticelli C. Modification of alpha-chain or beta-chain heme pocket polarity by Val(E11) –> thr substitution has different effects on the steric, dynamic, and functional properties of human recombinant hemoglobin. Deoxy derivatives. J Biol Chem. 1997 Oct 17;272(42):26271-8. doi: 10.1074/jbc.272.42.26271. PubMed PMID: 9334196.
  40. Chung D, Amar S, Glozman A, Chen JM, Friedman FK, Robinson R, Monaco R, Brandt-Rauf P, Yamaizumi Z, Pincus MR.Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations. J Protein Chem. 1997 Aug;16(6):631-5. PubMed PMID: 9263125.
  41. Chen JM, Monaco R, Manolatos S, Brandt-Rauf PW, Friedman FK, Pincus MR. Molecular dynamics on complexes of ras-p21 and its inhibitor protein, rap-1A, bound to the ras-binding domain of the raf-p74 protein: identification of effector domains in the raf protein. J Protein Chem. 1997 Aug;16(6):619-29. PubMed PMID: 9263124.
  42. Koley AP, Dai R, Robinson RC, Markowitz A, Friedman FK. Differential interaction of erythromycin with cytochromes P450 3A1/2 in the endoplasmic reticulum: a CO flash photolysis study. 1997 Mar 18;36(11):3237-41. doi: 10.1021/bi962110h. PubMed PMID: 9116001.
  43. Adler V, Pincus MR, Minamoto T, Fuchs SY, Bluth MJ, Brandt-Rauf PW, Friedman FK, Robinson RC, Chen JM, Wang XW, Harris CC, Ronai Z. Conformation-dependent phosphorylation of p53. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1686-91. doi: 10.1073/pnas.94.5.1686. PubMed PMID: 9050839; PubMed Central PMCID: PMC19977.
  44. Koley AP, Robinson RC, Markowitz A, Friedman FK. Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4. Biochem Pharmacol. 1997 Feb 21;53(4):455-60. doi: 10.1016/s0006-2952(96)00836-2. PubMed PMID: 9105395.
  45. Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK. Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone. J Biol Chem. 1997 Feb 7;272(6):3149-52. doi: 10.1074/jbc.272.6.3149. PubMed PMID: 9013547.
  46. Sanna MT, Razynska A, Karavitis M, Koley AP, Friedman FK, Russu IM, Brinigar WS, Fronticelli C. Assembly of human hemoglobin. Studies with Escherichia coli-expressed alpha-globin. J Biol Chem. 1997 Feb 7;272(6):3478-86. doi: 10.1074/jbc.272.6.3478. PubMed PMID: 9013594.
  47. Dai R, Jacobson KA, Robinson RC, Friedman FK. Differential effects of flavonoids on testosterone-metabolizing cytochrome P450s. Life Sci. 1997;61(7):PL75-80. doi: 10.1016/s0024-3205(97)00541-9. PubMed PMID: 9252251.
  48. Amar S, Glozman A, Chung D, Adler V, Ronai Z, Friedman FK, Robinson R, Brandt-Rauf P, Yamaizumi Z, Pincus MR.Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents. Cancer Chemother Pharmacol.1997;41(1):79-85. doi: 10.1007/s002800050711. PubMed PMID: 9443618.
  49. Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study. Arch Biochem Biophys. 1996 Dec 15;336(2):261-7. doi: 10.1006/abbi.1996.0556. PubMed PMID: 8954573.
  50. Adler V, Pincus MR, Polotskaya A, Montano X, Friedman FK, Ronai Z. Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras. J Biol Chem. 1996 Sep 20;271(38):23304-9. doi: 10.1074/jbc.271.38.23304. PubMed PMID: 8798530.
  51. Hornstein EH, Vassilopoulos D, Thomas DE, Friedman FK, Tsokos GC. Modulation of human T-lymphocyte plasma membrane Ca2+ permeability by imidazole antimycotics. Immunopharmacol Immunotoxicol. 1996 May;18(2):237-45. doi: 10.3109/08923979609052734. PubMed PMID: 8771369.
  52. Koley AP, Robinson RC, Friedman FK. Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics. 1996;78(8-9):706-13. PubMed PMID: 9010599.
  53. Monaco R, Chen JM, Friedman FK, Brandt-Rauf P, Chung D, Pincus MR. Structural effects of the binding of GTP to the wild-type and oncogenic forms of the ras-gene-encoded p21 proteins. J Protein Chem. 1995 Nov;14(8):721-9. PubMed PMID: 8747433.
  54. Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK. CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers. J Biol Chem. 1995 Mar 10;270(10):5014-8. doi: 10.1074/jbc.270.10.5014. PubMed PMID: 7890608.
  55. Koley AP, Robinson RC, Markowitz A, Friedman FK. Interaction of polycyclic aromatic hydrocarbons and flavones with cytochromes P450 in the endoplasmic reticulum: effect on CO binding kinetics. 1995 Feb 14;34(6):1942-7. doi: 10.1021/bi00006a015. PubMed PMID: 7849053.
  56. Postnikov YV, Lehn DA, Robinson RC, Friedman FK, Shiloach J, Bustin M. The cooperative binding of chromosomal protein HMG-14 to nucleosome cores is reduced by single point mutations in the nucleosomal binding domain. Nucleic Acids Res. 1994 Oct 25;22(21):4520-6. doi: 10.1093/nar/22.21.4520. PubMed PMID: 7971283; PubMed Central PMCID: PMC308488.
  57. Omata Y, Sakamoto H, Robinson RC, Pincus MR, Friedman FK. Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1090-5. doi: 10.1006/bbrc.1994.1817. PubMed PMID: 8024550.
  58. Omata Y, Robinson RC, Gelboin HV, Pincus MR, Friedman FK. Specificity of the cytochrome P-450 interaction with cytochrome b5. FEBS Lett. 1994 Jun 13;346(2-3):241-5. doi: 10.1016/0014-5793(94)00482-x. PubMed PMID: 8013641.
  59. Koley AP, Robinson RC, Markowitz A, Friedman FK. Kinetics of CO binding to cytochromes P450 in the endoplasmic reticulum. 1994 Mar 8;33(9):2484-9. doi: 10.1021/bi00175a017. PubMed PMID: 8117709.
  60. Dykes DC, Friedman FK, Dykes SL, Murphy RB, Brandt-Rauf PW, Pincus MR. Molecular dynamics of the H-ras gene-encoded p21 protein; identification of flexible regions and possible effector domains. J Biomol Struct Dyn. 1993 Dec;11(3):443-58. doi: 10.1080/07391102.1993.10508009. PubMed PMID: 8129867.
  61. Shirakata M, Friedman FK, Wei Q, Paterson BM. Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by nonconserved hydrophilic residues. Genes Dev. 1993 Dec;7(12A):2456-70. doi: 10.1101/gad.7.12a.2456. PubMed PMID: 8253390.
  62. Dykes DC, Brandt-Rauf P, Luster SM, Friedman FK, Pincus MR. Activated conformations of the ras-gene-encoded p21 protein. 2. Comparison of the computed and high-resolution x-ray crystallographic structures of Gly-12 p21. J Biomol Struct Dyn. 1993 Apr;10(5):905-18. doi: 10.1080/07391102.1993.10508683. PubMed PMID: 8318164.
  63. Chung DL, Joran A, Friedman F, Robinson R, Brandt-Rauf PW, Weinstein IB, Ronai Z, Baskin L, Dykes DC, Murphy RB.Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms. Exp Cell Res. 1992 Dec;203(2):329-35. PubMed PMID: 1459198.
  64. Licht D, Cronstein B, Dykes DC, Pedersen J, Luster SM, Trampota M, Hull E, Friedman FK, Pincus MR. Correlation of the conformation of a modified ribonuclease octapeptide, homologous to peptide T, with its ability to induce CD4-dependent monocyte chemotaxis. J Protein Chem. 1992 Oct;11(5):475-81. PubMed PMID: 1449597.
  65. Omata Y, Friedman FK. Cytochrome P450-benzphetamine interactions in the endoplasmic reticulum: studies using a monoclonal antibody to P450b. 1992 Sep 22;31(37):8862-7. doi: 10.1021/bi00152a024. PubMed PMID: 1390673.
  66. Omata Y, Friedman FK. The effect of dilauroyl-L-3-phosphatidylcholine on the interaction between cytochrome P-450 1A1 and benzo[a]pyrene. FEBS Lett. 1992 Sep 14;309(3):249-52. doi: 10.1016/0014-5793(92)80782-c. PubMed PMID: 1516694.
  67. Tsokos DC, Omata Y, Robinson RC, Krutzsch HC, Gelboin HV, Friedman FK. A proteolytically sensitive region common to several rat liver cytochromes P450: effect of cleavage on substrate binding. 1992 Aug 11;31(31):7155-9. doi: 10.1021/bi00146a018. PubMed PMID: 1643049.
  68. Dykes DC, Brandt-Rauf P, Luster SM, Chung D, Friedman FK, Pincus MR. Activated conformations of the ras-gene-encoded p21 protein. 1. An energy-refined structure for the normal p21 protein complexed with GDP. J Biomol Struct Dyn. 1992 Jun;9(6):1025-44. doi: 10.1080/07391102.1992.10507977. PubMed PMID: 1637501.
  69. Omata Y, Friedman FK. A fluorescence study of the interactions of benzo[a]pyrene, cytochrome P450c and NADPH-cytochrome P450 reductase. Biochem Pharmacol. 1991 Jun 21;42(1):97-101. doi: 10.1016/0006-2952(91)90686-y. PubMed PMID: 1906275.
  70. Carubelli R, Graham SA, McCay PB, Friedman FK. Prevention of 2-acetylaminofluorene-induced loss of nuclear envelope cytochrome P450 by the simultaneous administration of 3-methylcholanthrene. Biochem Pharmacol. 1991 May 1;41(9):1331-4. doi: 10.1016/0006-2952(91)90105-e. PubMed PMID: 2018565.
  71. Alston K, Robinson RC, Park SS, Gelboin HV, Friedman FK. Interactions among cytochromes P-450 in the endoplasmic reticulum. Detection of chemically cross-linked complexes with monoclonal antibodies. J Biol Chem. 1991 Jan 15;266(2):735-9. PubMed PMID: 1985961.
  72. Myers MJ, Liu G, Miller H, Gelboin HV, Robinson RC, Friedman FK. Synthetic peptide antigens elicit monoclonal and polyclonal antibodies to cytochrome P450 IA2. Biochem Biophys Res Commun. 1990 May 31;169(1):171-6. doi: 10.1016/0006-291x(90)91450-7. PubMed PMID: 2350341.
  73. Robinson RC, Nagata K, Gelboin HV, Rifkind J, Gonzalez FJ, Friedman FK. Developmental regulation of hepatic testosterone hydroxylases: simultaneous activation and repression of constitutively expressed cytochromes P450 in senescent rats. Arch Biochem Biophys. 1990 Feb 15;277(1):42-6. doi: 10.1016/0003-9861(90)90547-c. PubMed PMID: 2306123.
  74. Wilson JD, Miller H, Gelboin HV, Friedman FK. Variation in inducibility of cytochrome P-450c and aryl hydrocarbon hydroxylase in rat liver, lung, kidney, pancreas and nasopharynx. 1990;41(5):256-62. doi: 10.1159/000138729. PubMed PMID: 2092329.
  75. Friedman FK, Miller H, Park SS, Graham SA, Gelboin HV, Carubelli R. Induction of rat liver microsomal and nuclear cytochrome P-450 by dietary 2-acetylaminofluorene and butylated hydroxytoluene. Biochem Pharmacol. 1989 Sep 15;38(18):3075-81. doi: 10.1016/0006-2952(89)90018-x. PubMed PMID: 2783162.
  76. Lorr NA, Bloom SE, Park SS, Gelboin HV, Miller H, Friedman FK. Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms. Mol Pharmacol. 1989 May;35(5):610-6. PubMed PMID: 2725470.
  77. Friedman FK, Robinson RC, Rifkind J. Age-related changes in the iron spin state of testosterone-binding rat liver microsomal cytochromes P-450. Biochem Biophys Res Commun. 1989 Jan 31;158(2):480-4. doi: 10.1016/s0006-291x(89)80073-7. PubMed PMID: 2537074.
  78. Robinson RC, Shorr RG, Varrichio A, Park SS, Gelboin HV, Miller H, Friedman FK. Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation. 1989;39(3):137-44. doi: 10.1159/000138590. PubMed PMID: 2587619.
  79. Ueng TH, Friedman FK, Miller H, Park SS, Gelboin HV, Alvares AP. Studies on ethanol-inducible cytochrome P-450 in rabbit liver, lungs and kidneys. Biochem Pharmacol. 1987 Aug 15;36(16):2689-91. doi: 10.1016/0006-2952(87)90554-5. PubMed PMID: 3606668.
  80. Pasanen M, Pelkonen O, Kauppila A, Park SS, Friedman FK, Gelboin HV. Characterization of human fetal hepatic cytochrome P-450-associated 7-ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase activities by monoclonal antibodies. Dev Pharmacol Ther. 1987;10(2):125-32. PubMed PMID: 3608743.
  81. Robinson RC, Cheng KC, Park SS, Gelboin HV, Friedman FK. Structural comparison of monoclonal antibody immunopurified pulmonary and hepatic cytochrome P-450 from 3-methylcholanthrene-treated rats. Biochem Pharmacol. 1986 Nov 1;35(21):3827-30. doi: 10.1016/0006-2952(86)90671-4. PubMed PMID: 3778507.
  82. Pelkonen O, Pasanen M, Kuha H, Gachalyi B, Kairaluoma M, Sotaniemi EA, Park SS, Friedman FK, Gelboin HV. The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. Br J Clin Pharmacol. 1986 Aug;22(2):125-34. doi: 10.1111/j.1365-2125.1986.tb05239.x. PubMed PMID: 3756062; PubMed Central PMCID: PMC1401105.
  83. Cheng KC, Park SS, Krutzsch HC, Grantham PH, Gelboin HV, Friedman FK. Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. 1986 May 6;25(9):2397-402. doi: 10.1021/bi00357a015. PubMed PMID: 3718958.
  84. Hoy GR, Cook DC, Berger RL, Friedman FK. Mössbauer spectroscopic studies of hemoglobin and its isolated subunits.Biophys J. 1986 May;49(5):1009-15. doi: 10.1016/S0006-3495(86)83729-8. PubMed PMID: 3708086; PubMed Central PMCID: PMC1329681.
  85. Hietanen E, Malaveille C, Friedman FK, Park SS, Béréziat JC, Brun G, Bartsch H, Gelboin HV. Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice. Cancer Res. 1986 Feb;46(2):524-31. PubMed PMID: 3510075.
  86. Friedman FK, Park SS, Song BJ, Cheng KC, Fujino T, Gelboin HV. Monoclonal antibody-directed analysis of cytochrome P-450. Adv Exp Med Biol. 1986;197:145-54. doi: 10.1007/978-1-4684-5134-4_11. PubMed PMID: 3766255.
  87. Friedman FK, Robinson RC, Song BJ, Park SS, Gelboin HV. Preparation of catalytically active cytochromes P-450 by antigen exchange on monoclonal antibody based immunoadsorbents. 1985 Dec 3;24(25):7044-8. doi: 10.1021/bi00346a003. PubMed PMID: 4084558.
  88. Song BJ, Gelboin HV, Park SS, Friedman FK. Epitope-relatedness and phenotyping of hepatic cytochromes P-450 with monoclonal antibodies. Biochem J. 1985 Nov 1;231(3):671-6. doi: 10.1042/bj2310671. PubMed PMID: 2416310; PubMed Central PMCID: PMC1152801.
  89. Gelboin HV, Friedman FK. Monoclonal antibodies for studies on xenobiotic and endobiotic metabolism. Cytochromes P-450 as paradigm. Biochem Pharmacol. 1985 Jul 1;34(13):2225-34. doi: 10.1016/0006-2952(85)90776-2. Review. PubMed PMID: 3893437.
  90. Friedman FK, Robinson RC, Krutzsch HC, Grantham PH, Park SS, Gelboin HV. Monoclonal antibody directed isolation and amino-terminal sequence analysis of phenobarbital induced rat liver cytochromes P-450. Biochem Biophys Res Commun. 1985 Jun 28;129(3):926-33. doi: 10.1016/0006-291x(85)91980-1. PubMed PMID: 4015658.
  91. Friedman FK, Pastewka JV, Robinson RC, Park SS, Marletta MA, Gelboin HV. Monoclonal antibodies to cytochrome P-450 immunopurify a 45-kDa protein from a human lymphoblastoid cell line. FEBS Lett. 1985 Jun 3;185(1):67-70. doi: 10.1016/0014-5793(85)80742-0. PubMed PMID: 2581816.
  92. Friedman FK, Robinson RC, Song BJ, Park SS, Crespi CL, Marletta MA, Gelboin HV. Monoclonal antibody-directed determination of cytochrome P-450 types expressed in a human lymphoblastoid cell line. Mol Pharmacol. 1985 Jun;27(6):652-5. PubMed PMID: 3873598.
  93. Friedman FK, Robinson RC, Park SS, Gelboin HV. Catalytic activity of cytochromes P-450 purified by monoclonal antibody-directed immunopurification. Biochem Pharmacol. 1985 Jun 1;34(11):2051-4. doi: 10.1016/0006-2952(85)90336-3. PubMed PMID: 4004923.
  94. Song BJ, Gelboin HV, Park SS, Tsokos GC, Friedman FK. Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes. 1985 Apr 26;228(4698):490-2. doi: 10.1126/science.2580351. PubMed PMID: 2580351.
  95. Friedman FK, Park SS, Gelboin HV. The application of monoclonal antibodies for studies on cytochrome P-450. Rev Drug Metab Drug Interact. 1985;5(2-3):159-92. Review. PubMed PMID: 3915825.
  96. Friedman FK, West D, Dewick PM, Gelboin HV. Specificity of medicarpin and related isoflavonoids in inhibition of rat hepatic mixed function oxidase activity. 1985;31(5):289-93. doi: 10.1159/000138134. PubMed PMID: 3877941.
  97. Friedman FK, West D, Sugimura T, Gelboin HV. Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase.1985;31(4):203-7. doi: 10.1159/000138116. PubMed PMID: 4059325.
  98. Friedman FK, Wiebel FJ, Gelboin HV. Modulation of rat hepatic aryl hydrocarbon hydroxylase by various flavones and polycyclic aromatic hydrocarbons. 1985;31(4):194-202. doi: 10.1159/000138115. PubMed PMID: 4059324.
  99. Cheng KC, Gelboin HV, Song BJ, Park SS, Friedman FK. Detection and purification of cytochromes P-450 in animal tissues with monoclonal antibodies. J Biol Chem. 1984 Oct 10;259(19):12279-84. PubMed PMID: 6480608.
  100. Cheng KC, Krutzsch HC, Park SS, Grantham PH, Gelboin HV, Friedman FK. Amino-terminal sequence analysis of six cytochrome P-450 isozymes purified by monoclonal antibody directed immunopurification. Biochem Biophys Res Commun. 1984 Sep 28;123(3):1201-8. doi: 10.1016/s0006-291x(84)80260-0. PubMed PMID: 6487327.
  101. Rosenberg R, Koontz LC, Alston K, Friedman FK. Plasmodium gallinaceum: erythrocyte factor essential for zygote infection of Aedes aegypti. Exp Parasitol. 1984 Apr;57(2):158-64. PubMed PMID: 6714357.
  102. Song BJ, Fujino T, Park SS, Friedman FK, Gelboin HV. Monoclonal antibody-directed radioimmunoassay of specific cytochromes P-450. J Biol Chem. 1984 Feb 10;259(3):1394-7. PubMed PMID: 6693411.
  103. Alston K, Schechter AN, Arcoleo JP, Greer J, Parr GR, Friedman FK. Preparation and properties of nickel hemoglobin.Hemoglobin. 1984;8(1):47-60. PubMed PMID: 6547118.
  104. Friedman FK, Park SS, Fujino T, Song BJ, Robinson RC, West D, Radkowsky AK, Miller H, Gelboin HV. Phenotyping cytochromes P450 with monoclonal antibodies. Toxicol Pathol. 1984;12(2):155-61. doi: 10.1177/019262338401200207. PubMed PMID: 11478317.
  105. Friedman FK, Robinson RC, Park SS, Gelboin HV. Monoclonal antibody-directed immunopurification and identification of cytochromes P-450. Biochem Biophys Res Commun. 1983 Nov 15;116(3):859-65. doi: 10.1016/s0006-291x(83)80221-6. PubMed PMID: 6651850.
  106. Pflumm MN, Friedman FK, Fischer E, Beychok S. The effect of cupric ion on the reoxidation pathway of an IgG1 immunoglobulin. Biochem Biophys Res Commun. 1982 Nov 16;109(1):174-9. doi: 10.1016/0006-291x(82)91581-9. PubMed PMID: 7159420.
  107. Alston K, Friedman FK, Schechter AN. The solubility of hemoglobins A and S reconstituted with various metalloporphyrins. Hemoglobin. 1982;6(1):15-25. PubMed PMID: 7068432.
  108. Friedman FK, Alston K, Schechter AN. An improved method for the preparation of renaturable apohemoglobin chains.Anal Biochem. 1981 Oct;117(1):103-7. doi: 10.1016/0003-2697(81)90698-9. PubMed PMID: 7316185.
  109. Chang MY, Friedman FK, Beychok S, Shyong JS, Osserman EF. Further studies of the riboflavin-binding immunoglobulin IgGGar. Resolution into fractions of different riboflavin content and aspects of reassembly. Biochemistry. 1981 May 12;20(10):2916-21. doi: 10.1021/bi00513a031. PubMed PMID: 7248257.
  110. Chang MY, Friedman FK, Beychok S. Further studies on the riboflavin-binding immunoglobulin IgGGar. Equilibrium and kinetic aspects of the interaction. Biochemistry. 1981 May 12;20(10):2922-6. doi: 10.1021/bi00513a032. PubMed PMID: 7248258.
  111. Friedman FK, Beychok S. Probes of subunit assembly and reconstitution pathways in multisubunit proteins. Annu Rev Biochem. 1979;48:217-50. doi: 10.1146/annurev.bi.48.070179.001245. PubMed PMID: 157713.
  112. Friedman FK, Chang MY, Beychok S. Kinetics of interaction of heavy and light chains in immunoglobulins. Use of a sulfhydryl-specific light chain fluorescent probe. J Biol Chem. 1978 Apr 10;253(7):2368-72. PubMed PMID: 416030.
  113. Sears DW, Kazin AR, Mohrer J, Friedman F, Beychok S. Acquisition of the covalent quaternary structure of an immunoglobulin G molecule. Reoxidative assembly in vitro. Biochemistry. 1977 May 3;16(9):2016-25. doi: 10.1021/bi00628a040. PubMed PMID: 403936.
  114. Friedman F, Detwiler TC. Stimulus-secretion coupling in platelets. Effects of drugs on secretion on adenosine 5′-triphosphate. Biochemistry. 1975 Mar 25;14(6):1315-20. doi: 10.1021/bi00677a033. PubMed PMID: 164214.